Executing multicellular differentiation: quantitative predictive modelling of C.elegans vulval development

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Executing multicellular differentiation: quantitative predictive modelling of C.elegans vulval development

MOTIVATION Understanding the processes involved in multi-cellular pattern formation is a central problem of developmental biology, hopefully leading to many new insights, e.g. in the treatment of various diseases. Defining suitable computational techniques for development modelling, able to perform in silico simulation experiments, is an open and challenging problem. RESULTS Previously, we pr...

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Caenorhabditis elegans vulval development provides an important paradigm for studying the process of cell fate determination and pattern formation during animal development. Although many genes controlling vulval cell fate specification have been identified, how they orchestrate to generate a robust and invariant pattern of cell fates is not yet completely understood. Here, we have developed a ...

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Multicellular Development, Self-Organization, and Differentiation

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Caenorhabditis elegans vulval development provides an important paradigm for studying the process of cell fate determination and pattern formation during animal development. Although many genes controlling vulval cell fate specification have been identified, how they orchestrate themselves to generate a robust and invariant pattern of cell fates is not yet completely understood. Here, we have d...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2009

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btp509